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Request Approval of State Certified Pharmacy Technician ApplicationLatisha Ford, PhT Mr. Rose recused himself from voting in this matter. MOTION Dr. Richardson moved the Board deny this request. The motion was seconded by Mr. Banks and unanimously carried. * Request Approval of State Certified Pharmacy Technician Application Debbie Clark MOTION Mr. Rose made a motion seconded by Mr. Banks and unanimously carried that the Board deny this request.
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Effects of insulin signaling failure on learning abilities and on neuronal activity in animal models of type 2 Diabetes Supervisors: Dr. Christian Holscher, Dr. Victor Gault Level: PhD Background to the project In type 2 diabetes, the insulin signaling cascade is dysfunctional and causes several physiological complications. One of the effects is that insulin receptors on neurons desensitise, and that neuronal activity and survival is compromised. It has been discovered recently that diabetes type 2 sufferers have an increased risk of developing Alzheimer's disease Luchsinger et al., 2004 ; . It is known that neurons carry insulin receptors, and it appears that the desensitisation of these receptors increases neurodegenerative processes Hlscher, 2005 ; . The project will analyse to what degree the ability of animals with type 2 diabetes to learn novel tasks is affected. Several learning tasks will be used to identify how short-term, longterm, and working memory is affected in different age groups. Tests that will be used are spatial cognition and navigation tasks such as the water maze and radial arm mazes, motor tasks, exploratory tasks. In addition, the neuronal activity and the synaptic activity of type 2 diabetic animals will be tested to investigate how the chronic alteration of insulin signaling will affect neurons. Previous work has shown that insulin receptors play a role in controlling transmitter release and synaptic plasticity. It will be tested to what degree synaptic plasticity is affected in transgenic mice. Synaptic plasticity is important for the development of memory, and impairments in synaptic plasticity will indicate that the cellular systems that underlie memory formation have been affected. Objectives of the research Transgenic mice and mice fed a diet that induces type 2 Diabetes will be tested in learning tasks at several ages. Some animals will receive insulin like analogues to control the blood sugar, while others will not receive such drugs. It will be analysed how the learning ability of different age groups correlates with age and with the amount of plaque formation in the brain. Tests that will be employed are Open Field assessments of motor activity and of exploratory behaviour, spatial tasks such as the 8-arm maze and the water maze, the T-maze a working memory task ; , and several conditioning tasks to analyse nonspatial and temporal learning ability. Synaptic activity and the inducibility of synaptic plasticity will be tested in vivo by electrophysiological methods that stimulate neuronal activity and monitor synaptic activity. The accumulation of amyloid in the brains of diabetic mice will be tested using histological immunochemical methods and microscopy. References Hlscher C 2005 ; Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies. Rev Neurosci 16: 181-212. Luchsinger JA, Tang MX, Shea S, Mayeux R 2004 ; Hyperinsulinemia and risk of Alzheimer disease. Neurology 63: 1187-1192 and medroxyprogesterone. Agata Mulak, Leszek Paradowski, Department of Gastroenterology and Hepatology, Wroclaw Medical University, Wroclaw, Poland Supported by the grant from GlaxoSmithKline Pharmaceuticals S.A. Correspondence to: Agata Mulak, MD, PhD, Department of Gastroenterology and Hepatology, Wroclaw Medical University, Poniatowskiego 2, 50-326 Wroclaw, Poland. agata.mulak wp Telephone: + 48-71-3229918 Fax: + 48-71-3224401 Received: 2005-09-08 Accepted: 2005-11-18.

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Question 12: Should you report other pathogens present on a culture specific for one organism. Example rule out group A streptococci, GC cultures ; At Cleveland Clinic physicians tell us what they want with vaginal specimens: Group B Streptococcus, Trichomonas, Gardnerella vaginalis, gonorrhea, Chlamydia. We just look for those organisms. If we see heavy growth of Staphylococcus aureus we report that. It is specimen driven. If you get an organism out of the ordinary from a culturethat is not mentioned in the procedure manual, call the physician and find out what is going on with the patient. AT Children's in Philadelphia, we just report what we are ruling out. On GC cultures in abused children, we report out the presence of Neisseria gonorrhoeae with culture not PCR. CDC states that this needs to be done. In addition, it has been documented in the literature that GI pathogens have been found to be significant in girls that have been abused. Question 13: In our institution, the infectious disease doctors, pharmacy and microbiology laboratory meet yearly to decide which drugs we will selectively report for each organism. Recently, a family practice physician demanded that all drugs tested be made available routinely on the patient report. The pathologist overseeing our microbiology laboratory agrees with this physician. He believes that the medical staff has a right to know all results that are available, that it is demeaning to the medical staff to suppress results. How would you handle this situation? Physicians need to go through the pharmacy committee. A lot of thought went into antimicrobial agent reporting from CLSI. It earns astra zeneca the drug's maker ; 6 billion dollars per year, for instance, leevaquin for sinus infection.
AOK Baden-Wurttemberg and member of the board at Initiative D 21, stressed the importance of introducing new IT-systems, stating: `Patients should never look at their files without supervision, because they may find some rather unpleasant things, ' whereupon, Karl Lauterbach vehemently demanded: `They must!' Christa Stewens, Bavarian Minister for Employment and Social Affairs, Families and Women's Issues, spoke of Ingolstadt, a pilot project in which patients are the `master of their data' - aimed to reduce mistrust. `One develops a different approach to one's health, ' the minister said, before describing another 24 current projects on the teleconsultation, teleradiology, telemonitoring and teletherapy as well as electronic treatments. Christa Stewens then introduced the model project Donaustauf, which involves telemonitoring for 900 patients. Professor Michael Pfeifer MD, Medical Director of the Hospital Donaustauf, near Regensburg, described the first practical experi.

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