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A 30-year-old, gravida 1, para 0, aborta 0, right-handed woman was admitted to the hospital for induction of labor at 41 weeks of pregnancy. Her medical history was not significant. She was on no regular medication. The pregnancy was uneventful except for a low-percentile fetal growth curve throughout. On admission, blood pressure was 120 80 mm Hg, and Hb was 136 g L. Labor was induced with oxytocin in a 5% dextrose-water 25% saline solution. Six hours later, she delivered a 3153-g girl with an Apgar score of 8 10 and 10 minutes, and placental expulsion was complete. Three hours later, she had an episode of vomiting, and uterine bleeding with clot formation was noticed. She underwent a uterine revision under 5 mg intravenous midazolam hydrochloride. At that time blood pressure was 90 60 mmHg, and Hb decreased to 76 g Six hours after delivery, three generalized tonicoclonic convulsions of 1 minute's duration occurred. She received a transfusion and a loading dose of phenytoin sodium.
Pharmacological treatment There is a paucity of studies assessing safety and efficacy of medication in children and adolescents with bipolar disorder. First-line medications include mood stabilisers such as lithium Camcolit, Priadel ; , carbamazepine Tegretol ; and sodium valproate Epilim ; . The overall lithium response is often less than in adults, possibly due to the frequency of mixed symptoms of depression and elation irritability. Concerns regarding polycystic ovarian syndrome may limit the use of valproate in teenage girls, which is otherwise particularly effective for rapid cycling and mixed states. A pregnancy test should be carried out on teenage girls before commencing any medication with potential teratogenic effects, especially when manic symptoms are present and sexual disinhibition a possibility. Atypical antipsychotics, such as olanzapine Zyprexa ; , quetiapine Seroquel ; or risperidone Risperdal ; may also be considered first line, particularly in the presence of psychotic symptoms.9 Extrapyramidal side effects and neurotoxicity need to be assessed. A trial of four to six weeks at full dose should be tried before changing to another drug. If partial improvement is seen with monotherapy, augmentation could be considered, e.g. mood stabiliser and an atypical antipsychotic. Occasionally benzodiazepines are used as an adjunctive. More… posted in breastfeeding healthy breastfeeding tips for you and your baby we’ ve all heard the debate.

Carbimazole has rarely been associated with bone marrow suppression and treatment should be stopped promptly if there is clinical or laboratory evidence of neutropenia. Patients should be asked to report symptoms and signs suggestive of infection, especially sore throat. A white blood cell count should be performed if there is any clinical evidence of infection. Propylthiouracil may be an alternative for patients who suffer sensitivity reactions to carbimazole. Thyrotoxic crisis needs emergency specialist treatment including all, or combinations of, medications such as intravenous fluids, propranolol 5mg ; , hydrocortisone sodium succinate 100mg every 6 hours ; , potassium iodide, carbimazole. Pregnant patients receiving carbimazole must be monitored and administered the lowest effective dose. b ; beta-blockers.
Most people who take this medication do not have serious or bothersome side effects. Guanfacine hcl guanfacine hcl is a prescription or over-the-counter drug which is or once was ; approved in the united states and possibly in other countries and stavudine. Either way, labels can be used to gauge the amount of sodium present in various foods and to select lower sodium options. Characteristic Demographic factor Male Female Nursing home resident Comorbid illnesses Neoplastic disease Liver disease Congestive heart failure Cerebrovascular disease Renal disease * Physical examination finding Altered mental status + Respiratory rate 30 breaths min Systolic blood pressure 90 mmHg Temperature 35N C or 40N C Pulse 125 beats min Laboratory or radiographic finding Arterial pH 7.35 Blood urea nitrogen 30 mg dL Ssodium 130 mEq L Glucose 250 mg dL Hematocrit 30% Arterial partial pressure of oxygen 60 mmHg + Pleural effusion Risk Class I II III IV V No. of Points No predictors # 70 71-90 91-130 Mortality % ; 0.1 0.6 2.8 Points Assigned * Age years ; Age years ; 10 + 10 Recommended Site of Care Outpatient Outpatient Outpatient Hospital Hospital and zerit.

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Some studies suggest that exposing juvenile animals to stimulants makes them less likely to self-administer drugs such as cocaine when they are offered the drugs as adults, but other studies indicate the opposite and ticlid.
These data support the recommendation of the sixth report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure for low-dose diuretic or possibly beta-blocker ; therapy for hypertensive patients who have no specific indication for another antihypertensive drug jama, 2003; 2 73-2082; site.
Application "ANDA" ; No. 78-723 with the Food and Drug Administration "FDA" ; , for generic tablets containing 4 milligrams and 5 milligrams of montelukast sodium. Teva USA's ANDA contains a certification of invalidity, unenforceability, and or noninfringement of the '473 patent. Notice of that certification, but not the certification itself, was transmitted to MSD and Merck on or after April 2, 2007, and was received by them on April 4, 2007. 20. Teva USA had no adequate good faith basis for filing its ANDA containing a and ticlopidine.

MEDI 384 Discovery of the VEGFR-2 inhibitor BAY 57-9352: The synthesis and SAR of phthalazine and isoquinoline analogs Wendy Lee1, Stephen J. Boyer1, Catherine R. Brennan1, Jennifer M. Burke1, William Collibee1, Jacques Dumas1, Holia Hatoum-Mokdad1, Danielle Holmes1, Zhenqui Hong1, Harold C. Kluender1, Dhanapalan Nagarathnam1, Robert N. Sibley1, Ning Su1, Wai Wong1, James Elting2, Randall M. Jones2, Mark McHugh2, and Guochang Zhu2. 1 ; Department of Chemistry Research, Bayer HealthCare Pharmaceuticals Corporation, 400 Morgan Lane, West Haven, CT 06516, wendy.lee.b bayer , 2 ; Department of Cancer Research, Bayer HealthCare Pharmaceuticals Corporation Vascular endothelial growth factor VEGF ; and its receptor tyrosine kinase VEGFR-2 are key mediators of angiogenesis. Since the growth of new blood vessels is an important step in tumor progression, inhibition of VEGFR-2 has become a major area of research for the treatment of solid tumors. We recently disclosed the furopyridazine BAY 57-9352, a potent, orally active VEGFR-2, PDGFR, and c-kit inhibitor currently in Phase I clinical trials. In this poster, we wish to report early lead generation efforts leading to the discovery of BAY 57-9352. The synthesis and evaluation of phthalazine and isoquinoline analogs will be described. Exploration of the lower pyridyl fragment in both series led to the identification of the 2carboxamidopyridyl moiety as a preferred hinge-binding element. MEDI 385.
MS.100 Antirheumatics 1. Acetylsalicylic Tablet, 75mg, 100mg soluble ; , 300mg, 324mg microfined ; , 500mg enteric Acid coated ; 2. Diclofenac S0dium Injection, 25mg ml, 3ml ampoule Suppository, 100mg Tablet e c ; , 25mg, 50mg 3. Ibuprofen Capsule, 300mg Syrup, 100mg 5ml Tablet, 200mg, 400mg 4. Indomethacin Capsule, 25mg, 50mg, 75mg Suppository, 100mg Syrup 25mg 5ml 5. Phenylbutazone Injection, 20% in 3ml ampoule 6. Piroxicam Capsule, 10mg, 20mg Suppository, 20mg Tablet, 10mg, 20mg 7. Sulphasalazine Tablet e c ; , 500mg 8. Tenoxicam Suppository, 20mg Tablet, 20mg 9. Tolmetin sodium Capsule, 200mg, 400mg Tablet, 200mg MS.200 Drugs used for gout 1. Allopurinol 2. Colchicine Tablet, 100mg Injection, 0.5mg ml in 2ml ampoule Tablet, 0.5mg 3. Ibuprofen Tablet, 200mg, 400mg 4. Indomethacin Capsule, 25mg Suppository, 100mg 5. Probenecid Tablet, 500mg and tegaserod. The State of Florida was the focal point of a successful effort during fiscal 2001 to remove a decades-old barrier to substitution for Warfarin. On June 1, 2001, Florida Governor Jeb Bush signed HB 69, legislation that will modernize Florida's generic substitution regulations and permit the substitution of "AB" rated generic products for their brand name equivalents, including Warfarin Sodium. In signing the landmark legislation, the Governor said, "This bill will provide Floridians, particularly elders, with an opportunity to purchase quality drugs at a more affordable price." Based on current sales of Coumadin, and other drugs currently restricted by Florida's negative formulary, Florida patients should save $15-20 million each year. Introduction: The aim of the study is to evaluate the qualities of the deceased donor that may affect outcome of renal transplantation. Methods: This study was retrospectively conducted from the year 2003-2005. The donor qualities includes the age, gender, causes of death, the duration from admission to retrieval of organs, serum creatinine SCr ; and plasma sodium level at admission and at harvesting and zelnorm!

Tion that patients who tolerate enteral feedings are intrinsically less likely than patients who do not to have bleeding.27 Pharmacological Prophylaxis The American Society of HealthSystem Pharmacists Commission on Therapeutics has developed guidelines for stress ulcer prophylaxis based on studies in which 1 ; clinically important bleeding was used as a study end point and 2 ; prophylaxis was compared with no prophylaxis. Stress ulcer prophylaxis is recommended for adults admitted to the ICU who2 have coagulopathy, require mechanical ventilation for more than 48 hours, have a history of gastrointestinal ulceration or bleeding within 1 year before admission, or have at least 2 of the following risk factors: sepsis, ICU stay longer than 1 week, occult bleeding lasting 6 days or longer, and use of more than 250 mg hydrocortisone or the equivalent. These recommendations do not apply to patients with single-system injuries such as head trauma, spinal cord injury, or thermal injury; patients with these injuries were excluded from studies in which subjects were randomized to receive prophylaxis or no prophylaxis.2 In general, few studies with clinically important bleeding as an end point have indicated significant differences between the medications used for prophylaxis. However, the sample sizes needed to detect clinically important bleeding, a relatively rare event, were insufficient to preclude a type II statistical error. Comparative studies that have shown substantial dif, for example, sodium hydroxide msds. This is the same issue i have - i more upset at the fact of the information provided - i was told it was perfectly safe to use and i was given pills as early as 17 weeks and tibolone.

Executive NHS. Guidance on commissioning cancer services: Improving outcomes in upper gastro-intestinal cancers: The Manual. London: NHS Executive; 2001. New Zealand Health Information Service. Cancer: new registrations and deaths 1997. Wellington: Ministry of Health; 2001. 6. Lagergren J, Bergstrom R, Lindgren A, Nyren O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 1999; 340: 825-31. Chow WH, Blot WJ, Vaughan TL et al. Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia. J Natl Can Inst 1998; 90: 150-5. Borch K, Jonsson B, Tarpila E et al. Changing pattern of histological type, location, stage and outcome of surgical treatment of gastric carcinoma. Br J Surg 2000; 87: 618-26. Damhuis RA, Tilanus HW. The influence of age on resection rates and postoperative mortality in 273 patients with gastric cancer. Eur J Cancer 1995; 31A: 928-31. Hundahl SA, Menck HR, Mansour EG, Winchester DP. The national cancer data base report on gastric carcinoma. Cancer 1997; 80: 2333-41. Described before 19 ; . Cryostat sections 8 m ; of rat mammary gland were mounted on Silane precoated glass slides and fixed by immersion for 10 min in 4% paraformaldehyde PFA ; . Tissue sections were treated with 0.1 N HCl 10 min ; , washed in 1 PBS, and air dried 20 min ; . Each section was covered with 100 l of hybridization buffer 50% formamide, 1 Denhardt's, 10 mM triethanolamine, 5 mM EDTA, 6.25% dextran sulfate, 0.3 M NaCl, 1 mg ml tRNA ; containing 100 ng 100 l PEPT2-specific DIG-labeled sense or antisense cRNA probe. After hybridization, sections were washed twice for 15 min at 60C in 5 standard sodium citrate SSC ; and twice for 15 min at 65C in 1 SSC, followed by two 15-min washes at 60C in 0.1 SSC. Subsequently, the sections were treated with 20 g ml RNase A to remove unhybridized single-stranded RNA. Detection and development of hybridization signals were carried out as described above and in the manufacturer's commercial DIG-detection kit protocol Boehringer Mannheim ; . Slides were mounted in 50% glycerol in 1 PBS pH 7.4 ; . Immunohistochemistry. Immunohistochemistry was carried out on 4% PFA-fixed rat mammary gland specimens. Cryostat sections 8 m ; were washed several times in PBS and preincubated for 1 h at room temperature with 2% low-fat milk powder in Tris-buffered saline Tween 20 TBST ; , pH 7.4. Sections were incubated with polyclonal anti-rabbit PEPT2 serum 10 ; diluted 1: 000 in the preincubation solution overnight. As secondary antibody, an indocarbocyanin antibody 1: 000, Dianova, Hamburg, Germany ; was used. Specificity of the antibody reaction was verified in parallel sections, which were incubated either with the primary antiserum that had been preabsorbed with the corresponding antigenic peptide concentration 20 g protein ml diluted antiserum ; or with only the secondary antibodies. Slides were coverslipped in carbonate-buffered glycerol pH 8.6 ; and viewed using epifluorescence microscopy. Two-electrode voltage clamp recording of transport currents mediated by PEPT2. Surgically removed Xenopus laevis oocytes were separated by collagenase treatment and handled as described previously 3 ; . Individual oocytes were injected with 50 nl of water controls ; or 50 nl RNA solution containing 30 ng of the PEPT2 complementary RNA cRNA ; . The two-electrode voltage clamp TEVC ; technique was applied to characterize responses in inward current to substrate addition in oocytes expressing PEPT2, as described previously 3 ; . Inward currents were measured in a buffer composed of 100 mM NaCl, 3 mM KCl, 1 mM CaCl2, 1 mM MgCl2, and 5 mM MES-Tris, pH 6.5, in the absence and the presence of 5 mM either free amino acids or selected dipeptides, with water-injected oocytes serving as controls. Membrane potential in oocytes was clamped to 100 mV, and 5 mM of Gly-L-Gln was used to standardize measurements between different batches of oocytes. Immunocytochemistry. For immunocytochemistry, 4% PFA immersion-fixed X. laevis oocytes were cut into 6- m cryostat sections, rinsed in PBS, covered with 2% low-fat milk powder in TBST, pH 7.4, for 1 h at room temperature, and then incubated with polyclonal anti-rabbit PEPT2 serum 10 ; diluted 1: 000 overnight. For detection of the primary antibody, anti-mouse fluorescein-5-isocyanate antiserum 1: 400, Amersham, Braunschweig, Germany ; was used. Transmission electron microscopy. Six PEPT2-injected oocytes were immersion fixed by incubation with potassium phosphate-buffered 2.5% glutaraldehyde solution pH 7.4, effective osmolarity 340 mosM ; for 2 h. Subsequently, samples were postfixed with 1% osmium tetroxide, dehydrated in a graded series of alcohol, and embedded in Spurr's medium and tinidazole.
References 1. #Singulair, montelukast s0dium tablets and chewable tablets$ [product monograph]. Kirkland QC ; : Merck Frosst Canada; 1999. 2. #Accolate, zafirlukast tablets$ [product monograph]. Mississauga ON ; : Zeneca Pharma; 1997. 3. Wenzel SE. Antileukotriene drugs in the management of asthma. #JAMA$ 1998; 280 24 ; : 2068-9. 4. Churg A, Churg J. Steroids and ChurgStrauss syndrome. #Lancet$ 1998; 352: 323. Wechsler ME, Garpestad E, Flier SR, Kocher O, Weiland DA, Polito AJ, et al. Pulmonary infiltrates, eosinophlia, and cardiomyopathy following corticosteroid withdrawal in patients with asthma receiving zafirlukast. #JAMA$ 1998; 279 6 ; : 455-7. 6. Green RL, Vayonis AG. ChurgStrauss syndrome after zafirlukast in two patients not receiving systemic steroid treatment. #Lancet$ 1999; 353: 725-6. Katz RS, Papernik M. Zafirlukast and ChurgStrauss syndrome. #JAMA$ 1998; 279 24 ; : 1949; discussion 1950. 8. Katial RK, Stelzle RC, Bonner MW, Marino M, Cantilena LR, Smith LJ. A drug interaction between zafirlukast and theophylline. #Arch Intern Med$ 1998; 158 15 ; : 1713-5. 9. Smith LF. A risk-benefit assessment of antileukotrienes in asthma. #Drug Safety$ 1998; 19 3 ; : 205-18. It can take 2-3 months to get the full effect of the medicine, so be patient and tiotropium and sodium, because sodikm nitrate. India remains a key engine of world growth with a consistently good growth rate well in excess of 6.5%; investor confidence in our nation and the mood of the business indicates that India's economic growth is a story that is here to stay. Yet most of the news that we hear continues to be disheartening and reflective of the sustained failures of the executive. From mismanagement of emergencies such as floods and droughts to farmer's suicides to famines; why is it that the state always appears to be reactive rather than preventing the situation from going out of hand? A recent UN report on India indicates that there is more hunger in India today than in the 90s! The report states that 50% of India's women and kids suffer from severe malnutrition! Whilst it is easy to shrug this off cynically as a result of inherited poverty, it is also equally true that falling agricultural wages and increasing landlessness have contributed to this significant deprivation of one's right to food. Incidents which show the overbearing and arrogant attitude of administrators and bureaucrats are never uncommon in India. It was therefore not shocking at all, but rather amusing to find the state CM first encouraging a suspension of a diligent MSEB employee for having cut power supply to his quarters over non-payment of dues and then revoking the suspension orders under intense media pressure. Also, education cess money was used in the state to sponsor a scam which benefited 12 lakh non-existent students to the tune of Rs 725 crores! What is happening here, Mantriji? Recently, the CGSI carried out a study on the quality of edible oils sold loose in the market; it was found that groundnut oil in all the samples studied was found to be adulterated heavily leading us to ponder whether the oil is from groundnuts or whether the name of the oil is "groundnut brand oil"?!! Our findings in this connection were reported in the TOI, Sep 11, 2006, pg 20 under the title "Consumer's body unearths adulteration of groundnut oil". The report on this study is also included in this issue. The 2nd largest vegetable producer in the world, India also has the dubious record of wasting as much as $ 15 billion worth of food items every year. Horticultural packaging if implemented diligently can help significantly reduce such wastage. An article on recent trends in this field appears in this issue of Keemat. Dr. A. R. Shenoy. AND NOW IT'S TIME FOR ANOTHER ACCENTHEALTH MINDBENDER. DOES A PAP SMEAR TEST A WOMAN FOR.? A ; OVARIAN CANCER B ; CERVICAL CANCER C ; BOTH OVARIAN AND CERVICAL CANCER THINK ABOUT IT AND WE'LL BE RIGHT BACK WITH THE ANSWER WHEN ACCENTHEALTH RETURNS and tizanidine!

We will probably see a broadening of licensed anti-HIV therapy targets, from the very earliest stages of the HIV life cycle through the intermediate stage of integration to later stages such as maturation. This may have potential to transform strategic approaches to therapeutic management of HIV, changing when to start, what to start with, and providing new options to people with triple-class-resistant HIV. The obstacles to a better future for people with HIV are clear. The great majority of the world's people living with HIV and growing numbers even in the U.S. still lack easy access to simple, affordable, safe and effective treatment. There are many major players in the drug development process, the pharmaceutical industry pre-eminent among them. Continued vigilance, activism, and informed advocacy are crucial to fostering more enlightened drug development, approval, and post-marketing access and availability. Is there any body who's child is using this drug. D-Glucose anhydrous . 1000.0 HEPES in E15-007 and E15-808 5958.00 Phenol Red . 15.00 Soium Pyruvate . 110.00. The mechanisms responsible for the exercise intolerance of patients with chronic HF have not been defined clearly. Although HF is generally regarded as a hemodynamic disorder, many studies have indicated that there is a poor relation between measures of cardiac performance and the symptoms produced by the disease. Patients with a very low EF may be asymptomatic, whereas patients with preserved LVEF may have severe disability. The apparent discordance between EF and the degree of functional impairment is not well understood but may be explained in part by alterations in ventricular distensibility, valvular regurgitation, pericardial restraint, cardiac rhythm, conduction abnormalities, and right ventricular function 12 ; . In addition, in ambulatory patients, many noncardiac factors may contribute substantially to exercise intolerance. These factors include but are not limited to changes in peripheral vascular function, skeletal muscle physiology, pulmonary dynamics, neurohormonal and reflex autonomic activity, and renal soium handling. The existence of these noncardiac factors may explain why the hemodynamic improvement produced by therapeutic agents in patients with chronic HF may not be immediately or necessarily translated into clinical improvement. Although pharmacological interventions may produce rapid changes in hemodynamic variables, signs and symptoms may improve slowly over weeks or months or not at all. Ingredient amount loratadine, micronized 1 citric acid 48 sodium citrate 6 flavoring agent 1 glycerin 350 propylene glycol 100 sorbitol 150 sodium benzoate 1 disodium edta 25 saccharin 75 hydroxypropyl methylcellulose 5 water to make 0 ml this syrup is found to exhibit acceptable storage stability and stavudine. PARA TARTIARY BUTYL PHENOL OTHER MONOPHENOLS DIPHENYL OXIDE ALCHL PEROXIDES, ETHR PEROXIDES, KETONE NITRATED OR NITROSATED DERIVATIVES METHANAL FORMALDEHYDE ; BENZALDEHYDE ALDEHYDE-ALCOHOLS ACETONE IS0PH0R0N KETONE-ALCOHOLS & KETONE ALDEHYDES ACETIC ACID COBALT ACETATES ACETIC ANHYDRIDE ETHYL ACETATE VINYL ACETATE MONOCHLOROACETIC ACID, THR SALTS & ESTERS DICHLOROACETIC ACID, THEIR SALTS & ESTERS TRICHLORO ACETIC ACID, THEIR SALTS & ESTERS PALMITIC ACID STEARIC ACID GLYCEROL MONOSTEARATE HCO FATTY ACID INCL 12-HYDROXY STEARC ACD ; D.C.0. FATTY ACID OTHER PALMITIC ACID, STEARIC ACID & THEIR SALTS & ESTRS ACETYL CHL0RIDE OCTOIC ACID CAPRYLIC ACID ; HEXOIC ACID CAPROIC ACID ; OTHER SATRTD ACYLC MNOCRBIXYLC ACDS ETC & THR DRVTVS OLEIC ACID OTHER OLEIC LINOLEIC ACIDS & THEIR SALTS &ESTRS UNDECYLANIC ACID PHENYLACETIC ACID & ITS SALTS CINNAMIC ACID BISMUTH COMPOUNDS OF AROMATIC MONOACIDS POTASSIUM COMPOUNDS OF AROMATIC MONOACIDS SODIUM COMPOUNDS OF AROMATIC MONOACIDS ESTERS OF AROMATIC MONOACIDS NES OTHER ARMTC MONOCRBOXYLC ACDS & THR DRVTVS FUMBRIC ACID DIOCTYL ORTHOPHTHALATES BENZIDINE BENZIDINE DIHDROCHLORIDE 3: DICNLOROBEZIDINE DIHYDROCHLORIDE, SULPHATE AMFEPRA NONE INN ; , METHDONE & MORMETHADONESALTS OTHER AMINO-ALDEHYDES ETC CNTNG MORE THAN OXGN FN. SALTS LYSINE AND ITS ESTERS SALTS THEREOF ANTHRANILIC ACID AND ITS SALTS MEPROBAMATE INN ; FENPROPOREX INN ; & ITS SALTS ISONIAZID OTHR ORGNC DRVTS OF HYDRAZINE HYDRXYLMINE PEROXIDES & THR HALGNTD SLPHNTD.

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Definition, Indications and Contraindications. Initial management is defined as first line care action to be taken when any health professional identifies a woman with urinary incontinence. Urinary incontinence is defined as `the involuntary or inappropriate passing of urine .that has an impact on social functioning or hygiene. It also includes nocturnal enuresis bedwetting ; ' DOH, 2000 ; * . Indications: - to initiate an assessment, management and or treatment programme for the incontinent woman by an appropriately educated and competent practitioner. To refer a woman identified with urinary incontinence to an appropriately educated and competent practitioner for assessment, management and or treatment in the absence of expertise by the health professional who identifies the problem. Contraindications: - males and females who are not experiencing urinary incontinence.
ABSORPTION AND METABOLISM OF CHOLESTERYL 1- 14 C ; -OLEATE USING LIPID EMULSION AND SERUM LIPOPROTEIN Noor Aini, A.H. , Choong, M.L and Mohd. Azman, A.B. * Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia * Department of Biomedical Science, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia High serum cholesterol is a known risk factor for developing atherosclerosis. Formation of atherosclerosis is closely related to an increase in accumultion of cholesteryl ester and triglyceride in the arterial wall where most of the lipid comes from the plasma1 . A lot of in vitro studies using tissue culture and tissue slices had been done to study the absorption and metabolism of lipid by aorta3 . To study the absorption and metabolism of lipid in vitro using 'intact' aortic tissue and to establish the mechanism by which lipid is transported across the aortic wall. 18 adult rabbits were divided into two groups N 9 ; . The aorta was taken as soon as the rabbits were killed and immediately placed in the Using Chamber 2 . One group was incubated with cholesteryl 1- 14 C ; -oleate placed in lipoprotein extract from rabbit serum endogenous lipid ; . The labelled lipids were placed in the intimal compartment of the aorta and incubated for 90 minutes. The amount of lipid absorbed was determined by Liquid Scintillation Counter. The amount of cholesteryl 1-14 C ; -oleate absorbed and retained in the tissue was found to be 17.72 + 4.06 nmol cm2 90min mean + SEM ; using lipid emulsion, and 41.06 + 7.53 nmol cm2 90 min p 0.03 ; in the group where lipoprotein extract from rabbit serum was used. There was no significant difference in the amount of lipid secreted into the adventitial compartment. However the rate of lipid metabolism was higher in the latter group. The cholesteryl 1- 14 C ; -oleate was more readily absorbed and metabolised by aorta when the lipid was presented in lipoprotein extract as compared to an exogenous lipid emulsion. This may suggest that other factors are involved in lipid absorption and metabolism of aorta in vivo. 1. Lundberg B 1985 ; Chemical composition and physical site of lipid deposits in atherosclerosis. Atherosclerosis. 56: 93-110. 2. Noor Aini AH, Fadzil MH, Jamil MR, Megat R & Azman AB 1992 ; Pemampanan teknik in-vitro untuk kajian penyerapan dan metabolisme lipid oleh aorta. Pasca. Kol. Perubatan, 3: 217-220. 3. Stein O, Vander hock & Stein Y 1977 ; Cholesterol ester accumulation in cultured aortic smooth muscle cell. Atherosclerosis. 6: 465-482.

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